Epigenomics AG / Voting Rights: Release of a Voting Rights Notification (§ 21 para. 1 WpHG) in Accordance with § 26, para. 1 WpHG (German Securities Trading Act) with the Aim of an Europe-wide Distribution Publication pursuant to §26 sect.1 WpHG processed and transmitted by Hugin ASA. The issuer is solely responsible for the content of this announcement. ---------------------------------------------------------------------- --------------



Issuer:

Epigenomics AG - ISIN DE000A0BVT96 - Kleine Präsidentenstr. 1 10178 Berlin Deutschland

Voting Rights Notification:

On 21 August 2008 Federated Investors Inc., Pittsburgh, USA made the following notifications regarding the holding of voting rights held in Epigenomics AG, Berlin, Germany, according to § 21 WpHG in their name as well as for their subsidiary F II Holdings Inc., Pittsburgh, USA:

1.) Notification of voting rights in the name and on behalf of F II Holdings Inc. pursuant to § 21 para. 1 WpHG:

On 1 April 2008 F II Holdings Inc. fell below the 3 per cent, the 5 per cent, the 10 per cent and the 15 per cent thresholds of § 21 para. 1 WpHG and held at this date 0 per cent of the voting rights (0 voting rights) in Epigenomics AG.

2.) Notification of voting rights in their own name pursuant to § 21 para. 1 WpHG:

On 1 April 2008 Federated Investors Inc. fell below the 3 per cent, the 5 per cent, the 10 per cent and the 15 per cent thresholds of § 21 para. 1 WpHG and held at this date 0 per cent of the voting rights (0 voting rights) in Epigenomics AG.

Voluntary Clarification:

Further on the same day, Federated Investors Inc. made the following voluntary clarification in addition to their notifications pursuant to §§ 21 et seq. WpHG reported above regarding the holding of voting rights held in Epigenomics AG for Federated Kaufmann Fund Federated Investors Fund, Pittsburgh, USA as well as for Federated Equity Management Company of Pennsylvania, Pittsburgh, USA:

1.) Clarification of voting rights in the name and on behalf of the Federated Kaufmann Fund:

As of 1 April 2008 Federated Kaufmann Fund still held 19.02 per cent of the voting rights (5.081.706 voting rights) in Epigenomics AG.

2.) Clarification of voting rights in the name and on behalf of the of Federated Equity Management Company of Pennsylvania:

As of 1 April 2008 Federated Equity Management Company of Pennsylvania still held 19.26 per cent of the voting rights (5.143.405 voting rights) in Epigenomics AG. 19.26 per cent of the voting rights (5.143.405 voting rights) are attributed to Federated Equity Management Company of Pennsylvania pursuant to § 22 para. 1 sent. 1 no. 6 WpHG. Voting rights are attributed to Federated Equity Management Company of Pennsylvania by Federated Kaufmann Fund which held directly 3 per cent or more of voting rights.

Federated Investors Inc., are the parent company of F II Holdings Inc., which in turn is the parent company of Federated Equity Management Company of Pennsylvania. Federated Equity Management Company of Pennsylvania, an investment adviser registered in the United States under the Investment Company Act of 1940, acts as Investment Adviser to the Federated Kaufmann Fund and Federated Kaufmann Fund II, both Massachusetts Business Trusts and Investment Companies, as that term is defined under the Investment Company Act 1940.

Date of release: 22 August 2008

Epigenomics AG The Executive Board

Contact: Epigenomics AG Dr. Achim Plum Sr. Vice President Corporate Development Tel.: +49 (0)30 24345 368 Fax: +49 (0)30 24345 555 Email: achim.plum@epigenomics.com

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Epigenomics AG Kleine Präsidentenstr.1 Berlin Germany

WKN: A0BVT9; ISIN: DE000A0BVT96; Index: CDAX, Prime All Share, TECH All Share; Listed: Amtlicher Markt in Frankfurter Wertpapierbörse, Prime Standard in Frankfurter Wertpapierbörse, Freiverkehr in Börse Berlin, Freiverkehr in Börse Düsseldorf, Freiverkehr in Hanseatische Wertpapierbörse zu Hamburg, Freiverkehr in Bayerische Börse München, Freiverkehr in Börse Stuttgart;

Epigenomics AG

http://www.epigenomics.de

ISIN: DE000A0BVT96

Stock Identifier: XFRA.ECX

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