AXA Investment Managers UK Ltd; AXA IM UK Ltd/AXA Framlington IM Ltd:Rule 8.3 Protherics Plc

FORM 8.3 DEALINGS BY PERSONS WITH INTERESTS IN SECURITIES REPRESENTING 1% OR MORE (Rule 8.3 of the City Code on Takeovers and Mergers)

1. KEY INFORMATION

+-------------------------------------------------------------------+ | Name of person dealing (Note 1) | AXA Investment Managers UK | | | Limited/AXA Framlington | | | Investment Management Limited | |-----------------------------------+-------------------------------| | Company dealt in | Protherics Plc | |-----------------------------------+-------------------------------| | Class of relevant security to | Ordinary shares | | which the dealings being | | | disclosed relate (Note 2) | | |-----------------------------------+-------------------------------| | Date of dealing | 14/08/08 | +-------------------------------------------------------------------+



2. INTERESTS, SHORT POSITIONS AND RIGHTS TO SUBSCRIBE

(a) Interests and short positions (following dealing) in the class of relevant security dealt in (Note 3)

+-------------------------------------------------------------------------------------------+ | | Long | Short | | | | | |---------------+----------------------------+----------------------------------------------| | |Number |Number | | | (%) | (%) | |---------------+----------------------------+----------------------------------------------| |(1) Relevant |40, 101, 070 (11, 72%)| | |securities | | | | | | | |---------------+----------------------------+----------------------------------------------| |(2) Derivatives| | | |(other than | | | |options) | | | | | | | |---------------+----------------------------+----------------------------------------------| |(3) Options and| | | |agreements to | | | |purchase/sell | | | | | | | |---------------+----------------------------+----------------------------------------------| |Total |40, 101, 070 (11, 72%)| | | | | | +-------------------------------------------------------------------------------------------+

(b) Interests and short positions in relevant securities of the company, other than the class dealt in (Note 3)

+--------------------------------------------------------------------------+ |Class of | Long | Short | |relevant | | | |security: | | | | | | | |---------------+----------------------------+-----------------------------| | |Number |Number | | | (%) | (%) | |---------------+----------------------------+-----------------------------| |(1) Relevant | | | |securities | | | | | | | |---------------+----------------------------+-----------------------------| |(2) Derivatives| | | |(other than | | | |options) | | | | | | | |---------------+----------------------------+-----------------------------| |(3) Options and| | | |agreements to | | | |purchase/sell | | | | | | | |---------------+----------------------------+-----------------------------| |Total | | | | | | | +--------------------------------------------------------------------------+

(c) Rights to subscribe (Note 3)

+---------------------------------------+ | Class of relevant security: | Details | | | | |-----------------------------+---------| | | | +---------------------------------------+



3. DEALINGS (Note 4)

(a) Purchases and sales

+----------------------------------------------------------------+ | Purchase/sale | Number of securities | Price per unit (Note 5) | | | | | |---------------+----------------------+-------------------------| | Sale | 8, 000 | 0, 55p | +----------------------------------------------------------------+

(b) Derivatives transactions (other than options)

+-------------------------------------------------------------------+ | Product | Long/short (Note | Number of securities | Price per | | name, | 6) | (Note 7) | unit (Note | | e.g. CFD | | | 5) | |----------+------------------+------------------------+------------| | | | | | +-------------------------------------------------------------------+



(c) Options transactions in respect of existing securities (i) Writing, selling, purchasing or varying

+------------------------------------------------------------------------------------+ |Product |Writing, |Number of |Exercise|Type, e.g.|Expiry|Option money | |name, |selling, |securities to which|price |American, |date |paid/received | |e.g. call|purchasing, |the option relates | |European | |per unit (Note| |option |varying etc.|(Note 7) | |etc. | |5) | | | | | | | | | |---------+------------+-------------------+--------+----------+------+--------------| | | | | | | | | +------------------------------------------------------------------------------------+

(ii) Exercising

+-------------------------------------------------------------------+ | Product name, e.g. | Number of securities | Exercise price per | | call option | | unit (Note 5) | | | | | |--------------------+----------------------+-----------------------| | | | | | | | | +-------------------------------------------------------------------+

(d) Other dealings (including new securities) (Note 4)

+-------------------------------------------------------------------+ | Nature of transaction | Details | Price per unit (if applicable) | | (Note 8) | | (Note 5) | | | | | |-----------------------+---------+---------------------------------| | | | | | | | | +-------------------------------------------------------------------+

4. OTHER INFORMATION

Agreements, arrangements or understandings relating to options or derivatives

+-------------------------------------------------------------------+ | Full details of any agreement, arrangement or understanding | | between the person disclosing and any other person relating to | | the voting rights of any relevant securities under any option | | referred to on this form or relating to the voting rights or | | future acquisition or disposal of any relevant securities to | | which any derivative referred to on this form is referenced. If | | none, this should be stated. | |-------------------------------------------------------------------| | | | | | | +-------------------------------------------------------------------+



Is a Supplemental Form 8 attached? (Note 9) NO



+-------------------------------------------------------------------+ | Date of disclosure | 15/08/2008 | |---------------------------------------------------+---------------| | Contact name | Kyere Tabiri | |---------------------------------------------------+---------------| | Telephone number | 0207 003 1510 | |---------------------------------------------------+---------------| | If a connected EFM, name of offeree/offeror with | N/A | | which connected | | |---------------------------------------------------+---------------| | If a connected EFM, state nature of connection | N/A | | (Note 10) | | +-------------------------------------------------------------------+



Notes

The Notes on Form 8.3 can be viewed on the Takeover Panel's website at www.thetakeoverpanel.org.uk

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AXA Investment Managers UK Ltd

http://www.axa-im.com