Groundbreaking Results for Type 1 Diabetes and Kidney Health
Perth, Aug 23, 2024 AEST (ABN Newswire) - Proteomics International Laboratories Ltd (
ASX:PIQ), a pioneer in predictive diagnostics is pleased to announce groundbreaking results showing the PromarkerD predictive test can predict renal decline in type 1 diabetes.
- Breakthrough study is the first application of the PromarkerD test for predicting renal decline in type 1 diabetes
- Results show PromarkerD demonstrated high accuracy (area under the curve (AUC) of 0.93) in predicting chronic kidney disease in patients with type 1 diabetes
- PromarkerD has been previously validated for predicting renal decline up to four years in advance in type 2 diabetes
- The additional application for type 1 diabetes patients with their unique clinical needs offers a new target market for PromarkerD
- Global health impact: addresses a critical health issue for over 537 million people worldwide who have diabetes, with type 1 diabetes representing 10% of all cases
The results will be presented today in a study titled "Application of a validated prognostic protein biomarker test for renal decline in type 2 diabetes to type 1 diabetes: The Fremantle Diabetes Study Phase II " at the Australasian Diabetes Conference in Perth, Australia, held 21-23 August. The findings have also been accepted for publication in the journal of Clinical Diabetes and Endocrinology. This pioneering research marks the Company's first venture into the realm of type 1 diabetes.
The study addresses a significant gap in the medical field, focusing on the lack of prognostic biomarkers for chronic kidney disease (CKD) in individuals with type 1 diabetes. Utilizing the PromarkerD test, originally developed and validated for predicting renal decline in type 2 diabetes, researchers assessed its efficacy in a cohort of 92 individuals with type 1 diabetes from the Fremantle Diabetes Study Phase II.
The results are promising, with the PromarkerD test demonstrating strong predictive accuracy. The area under the receiver operating characteristic curve (AUC) was an impressive 0.93, indicating robust performance in predicting CKD risk and kidney function decline.
Proteomics International Managing Director Dr. Richard Lipscombe said, "This significant advancement highlights the versatility and robustness of the PromarkerD test. We are excited about the potential impact this could have on managing kidney health in both type 1 and type 2 diabetes patients."
Professor Tim Davis, consultant physician and endocrinologist at Fremantle Hospital and Professor of Medicine, University of Western Australia, and lead author on the study, said, "The early detection capabilities of PromarkerD are particularly beneficial for type 1 diabetes patients due to their unique clinical needs. By identifying at-risk individuals years before traditional methods, we can intervene sooner,potentially preventing significant renal complications and improving overall patient outcomes."
Diabetes affects over 537 million people worldwide, and chronic kidney disease is a major complication, leading to severe health outcomes and increased mortality. Type 1 diabetes represents approximately 10% of all cases of diabetes and cannot be prevented. Diabetes has emerged as the largest single cause of end-stage renal disease (leading to dialysis or kidney transplant) in developed and developing countries. These preliminary findings suggest that the PromarkerD test is a highly effective prognostic tool for renal decline in
both type 1 and type 2 diabetes, heralding a new era in diabetic kidney disease management.
PromarkerD has previously been validated as accurately predicting the onset of diabetic kidney disease (DKD) and future kidney function decline up to four years in advance in patients with type 2 diabetes.
Details: Australasian Diabetes Conference 2024, Oral presentation, titled:
Application of a validated prognostic protein biomarker test for renal decline in type 2 diabetes to type 1 diabetes:
The Fremantle Diabetes Study Phase II TME Davis, WA Davis, SD Bringans, JKC Lui, TSC Lumbantobing, H Lim , KE Peters, and RJ Lipscombe Medical School, The University of Western Australia, Fremantle Hospital, WA, Australia; Proteomics International, QEII Medical Centre, WA, Australia;
Summary of the Study
Aim: To assess the performance of the PromarkerD predictive test, which has been validated to predict future kidney function decline in patients with type 2 diabetes, in patients with type 1 diabetes.
Method: The baseline PromarkerD test score was determined using the PromarkerD immunoassay in 92 community-based individuals with confirmed type 1 diabetes recruited to the longitudinal observational Fremantle Diabetes Study Phase II. Changes in a patient's kidney function were measured by estimated glomerular filtration rate (eGFR). The performance of PromarkerD in predicting the risk of incident CKD (eGFR <60 mL/min/1.73m2 in people without CKD at baseline) or an eGFR decline of greater than or equal to30% over the next four years was determined.
Results: The area under the receiver operating characteristic curve (AUC) was 0.93 (95% confidence interval 0.87-0.99) for the composite renal endpoint, indicating excellent predictive accuracy. The optimal sensitivity, specificity, positive and negative predictive values were 78%, 90%, 47%, and 97%, respectively.
Conclusions: These preliminary data suggest that PromarkerD is at least as good a prognostic test for renal decline in type 1 as type 2 diabetes.
About PromarkerD (www.PromarkerD.com)
Diabetic kidney disease (DKD) is a serious complication arising from diabetes which if unchecked can lead to dialysis or kidney transplant. PromarkerD is a prognostic test that can predict future kidney function decline in patients with type 2 diabetes and no existing DKD. The patented PromarkerD test system uses a simple blood test to detect a unique 'fingerprint' of the early onset of the disease by measuring three serum protein biomarkers, combined with three routinely available conventional clinical variables (age, HDL cholesterol and estimated glomerular filtration rate (eGFR)). A cloud-based algorithm integrates the results into a patient risk report. In clinical studies published in leading journals PromarkerD correctly predicted up to 86% of otherwise healthy diabetics who went on to develop diabetic kidney disease within four years.
Further information is available through the PromarkerD web portal.
To visit the PromarkerD virtual booth please visit:
https://www.PromarkerD.com/product
To view the 2024 Annual Report, please visit:
https://www.abnnewswire.net/lnk/RALKS109
About Proteomics International Laboratories Ltd
Proteomics International Laboratories (ASX:PIQ) is a wholly owned subsidiary and trading name of PILL, a medical technology company at the forefront of predictive diagnostics and bioanalytical services. The Company specialises in the area of proteomics - the industrial scale study of the structure and function of proteins. Proteomics International's mission is to improve the quality of lives by the creation and application of innovative tools that enable the improved treatment of disease.
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